"it will be the end of mankind as we know it."

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The Lord of the Rings: The Return of the King (2003)
This will be the end of Gondor as we know it.
R.E.M. - It's The End Of The World
It's the end of the world as we know it
R.E.M. - It's The End Of The World
It's the end of the world as we know it.
R.E.M. - It's The End Of The World
It's the end of the world as we know it.
R.E.M. - It's The End Of The World
It's the end of the world as we know it.
Conquest of the Planet of the Apes (1972) Sci-Fi
If we lose this battle, that's the end of the world as we know it!
Bruce Almighty (2003)
and the worId as we know it may be coming to an end.
The Gods Must Be Crazy (1981)
Tomorrow I will take it to the end of the earth and throw it off.
R.E.M. - It's The End Of The World
It's the end of the world as we know it
Pirates of the Caribbean: At World's End (2007)
It will all have to be redone. All of it.
R.E.M. - It's The End Of The World
It's the end of the world as we know it.
Ishtar (1987)
It's uncanny, isn't it? it speaks of two messengers. And now we two have found it just as it foretold. and the mighty will be humbled.
The Matrix Reloaded (2003)
Goddamn it, woman, you will be the end of me.
Star Wars: Episode I - The Phantom Menace (1999)
Next time we race, boy, it will be the end of you.
R.E.M. - It's The End Of The World
It's the end of the world as we know it
R.E.M. - It's The End Of The World
It's the end of the world as we know it
Mr. Robot (2015) - S02E01
Meaning the end of the world as we know it.
R.E.M. - It's The End Of The World
It's the end of the world as we know it
R.E.M. - It's The End Of The World
It's the end of the world as we know it
R.E.M. - It's The End Of The World
It's the end of the world as we know it.